Paralysis Research Today is a free monthly online journal that collates and summarizes the latest research about Paralysis, including details on treatment, diagnosis, facial paralysis, sleep paralysis.

Response of intrathecal baclofen resistance to dose reduction.

Cooper JA, Ridley B

Spasticity Management Program, Alta Bates Summit Medical Center, Berkeley, CA, USA. Cooperj2@sutterhealth.org

Dose stabilization of intrathecal baclofen (ITB) is usually achieved within 6 to 18 months. In some patients, an increase in ITB dose may result in paradoxical unresponsiveness to baclofen. We present two cases demonstrating increased tone and functional decline with increasing ITB doses after a period of clinical stability. In both cases, reduction of ITB dose was associated with marked clinical improvement.

Published 24 October 2006 in Neurology, 67(8): 1495-6.
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