Paralysis Research Today is a free monthly online journal that collates and summarizes the latest research about Paralysis, including details on treatment, diagnosis, facial paralysis, sleep paralysis.

Chronic ataxic neuropathy mimicking dorsal midbrain syndrome.

Arbogast SD, Khanna S, Koontz DW, Tomsak RL, Katirji B, Leigh RJ

Department of Neurology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA.

We describe the clinical course, with special attention to the disturbance of eye movements, of a 29-year-old man with chronic ataxic neuropathy with ophthalmoplegia, IgM paraprotein, cold agglutinins and anti-GD1b disialosyl antibodies (CANOMAD). Using the magnetic search coil technique, we documented convergence during upward saccades and other features suggestive of dorsal midbrain syndrome. Thus, in common with Miller Fisher syndrome, CANOMAD may present with clinical findings implicating involvement of the central nervous system, which contains ganglioside antigens to anti-GD1b antibodies.

Published 17 October 2007 in J Neurol Neurosurg Psychiatry, 78(11): 1276-7.
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